Cases of thrombotic microangiopathy, including thrombotic thrombocytopenic purpura/hemolytic uremic syndrome (TTP/HUS), including fatal outcome have occurred. Access to Medicines Initiatives Outside the U.S. Non-Healthcare Donations and Sponsorships, http://www.prnewswire.com/news-releases/amgen-showcases-oncology-pipeline-at-asco-2020-301058857.html, Amgen Showcases Oncology Pipeline At ASCO 2020, In combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three lines of therapy, As a single agent for the treatment of patients with relapsed or refractory multiple myeloma who have received one or more lines of therapy. IMLYGIC then causes the cell to rupture and die in a process called lysis. "At ASCO, the data we are sharing reinforce our commitment to advancing first-in-class therapies that can alter the course of cancer care for patients who need it most.". The length of time that it takes for us to complete clinical trials and obtain regulatory approval for product marketing has in the past varied and we expect similar variability in the future. Pulmonary arterial hypertension (PAH) was reported. Amgen is one of the world’s leading biotechnology companies. Amgen has created a robust and differentiated pipeline, leveraging state-of-the-art science to create medicines for serious illness. Reduce or withhold dose as appropriate. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Injection Site Complications: Necrosis or ulceration of tumor tissue may occur during IMLYGIC, Impaired healing at the injection site has been reported. Please see full Prescribing Information at www.kyprolis.com. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers.

Adjust total fluid intake as clinically appropriate. About KYPROLIS® (carfilzomib) Proteasomes play an important role in cell function and growth by breaking down proteins that are damaged or no longer needed.4 KYPROLIS has been shown to block proteasomes, leading to an excessive build-up of proteins within cells.5 In some cells, KYPROLIS can cause cell death, especially in myeloma cells because they are more likely to contain a higher amount of abnormal proteins.4,5. About BiTE® Technology BiTE® (bispecific T cell engager) technology is a targeted immuno-oncology platform that is designed to engage patient's own T cells to any tumor-specific antigen, activating the cytotoxic potential of T cells to eliminate detectable cancer. Since its first approval in 2012, approximately 150,000 patients worldwide have received KYPROLIS. Acute renal failure was reported more frequently in patients with advanced relapsed and refractory multiple myeloma who received KYPROLIS monotherapy. KYPROLIS can cause fetal harm when administered to a pregnant woman. IMLYGIC is the first and only oncolytic viral therapy approved by the U.S. Food and Drug Administration (FDA), the European Medicines Agency (EMA), and other regulatory authorities, based on therapeutic benefit demonstrated in a pivotal Phase 3 study.
Monitor platelet counts frequently during treatment.

Amgen will present new data for AMG 510 (proposed INN: sotorasib) and AMG 160 during two oral presentations. Inform patients of the risk and of symptoms and seek immediate medical attention if they occur. Amgen's abstracts are available on the ASCO website and include: Amgen Webcast Investor Meeting Amgen will host a webcast call for the investment community in conjunction with the ASCO20 Virtual Scientific Program on Friday, May 29, at 1:00 p.m. PT. Withhold KYPROLIS for PAH until resolved or returned to baseline and consider whether to restart based on a benefit/risk assessment. An Introduction to Biotechnology . Advances in human genetics are pinpointing genes that cause disease and providing a new way to identify highly relevant drug targets. Amgen told FierceBiotech: “We made the difficult decision to end our research in neuroscience, which is largely based in Cambridge, Mass. The complexity of the human body cannot be perfectly, or sometimes, even adequately modeled by computer or cell culture systems or animal models. The thromboprophylaxis regimen should be based on an assessment of the patient's underlying risks. Caregivers should wear protective gloves when assisting patients in applying or changing occlusive dressings and observe safety precautions for disposal of used dressings, gloves, and cleaning materials.

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