Journal of Obstetric, Gynecologic & Neonatal Nursing, https://doi.org/10.1111/j.1552-6909.1994.tb01911.x. 2004 Spring;32(1):164-73. doi: 10.1111/j.1748-720x.2004.tb00462.x.

This study of the opinions of U.S. scientific experts about the ethical issues discussed in the literature on gene therapy contributes systematic data on the attitudes of those working in the field as well as elaborative comments. Most Americans are in favor of the development of therapies that may cure genetic diseases such as hypercholesterolemia, immune system dysfunctions, or cystic fibrosis. Adenovirus-mediated generation of cAMP-stimulated Cl- transport in cystic fibrosis airway epithelia in vitro: effect of promoter and administration method. Epub 2018 Jul 2. You are currently offline. 2000 Mar 9;404(6774):111 Ethical Issues in Gene Therapy THE ethics of gene therapy in humans has been discussed for many years and is being widely debated at present. The new DNA replaces only faulty DNA to cure genetic diseases. Rekindling RNAi Therapy: Materials Design Requirements for In Vivo siRNA Delivery. Germline therapy is a type of gene therapy where new DNA is inserted into cells using a vector, like a virus. -, Nat Biotechnol. 13, 1973). Sci Technol Human Values. A Review of Past and Present Hair Cell Regeneration Techniques, Cytokine-Modulating Strategies and Newer Cytokine Targets for Arthritis Therapy, Future Prospects of Gene Therapy for Treating CNS Diseases, Human Germline Genetic Modification: Issues and Options for Policymakers, Human gene therapy – the future of health care. Some features of the site may not work correctly.
To discern the ethical issues involved in current gene therapy research, to explore the problems inherent in possible future gene therapies, and to encourage debate within the scientific community about ethical questions relevant to both, we surveyed American Society of Human Genetics scientists who … Gene Therapy: Ethical Issues Theor Med Bioeth. 2006 Jun;32(6):361-4. doi: 10.1136/jme.2005.012740. Statement of J. Lejeune in B. Hilton, D. Callahan, M. Harris, P. Condliffe, B. Berkeley, eds., Ethical Issues in Human Genetics: Genetic Counseling and the Use of Genetic Knowledge, 70 (Fogarty International Proceedings No. -, Sci Technol Human Values. 2018 Sep;15(3):327-335. doi: 10.1007/s11673-018-9865-6. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error.  |  Corpus ID: 41803803. Our survey finds that respondents are highly supportive of the potential use of somatic cell gene therapy to cure serious diseases in adults and children as well as prospective offspring.

Human germline therapy : the case for its development and use, Journal of the South Carolina Medical Association, International journal of molecular sciences, By clicking accept or continuing to use the site, you agree to the terms outlined in our. On one hand, the technologies for gene transfer are still largely experimental and thus pose important safety issues. doi: 10.2196/jmir.2313.

2000 Apr;18(4):377

J Law Med Ethics. Genetic testing and its implications: human genetics researchers grapple with ethical issues. J Int Bioethique. Get the latest public health information from CDC: https://www.coronavirus.gov. Copyright © 1994 AWHONN, the Association of Women's Health, Obstetric and Neonatal Nurses. 2000 May 12;288(5468):951-7

-, Nature.

Get the latest research from NIH: https://www.nih.gov/coronavirus. Immediate issues are the control and confidentiality of results of genetic testing, possible discrimination against those found to have genetic diseases, and the just allocation of beneficial genetic therapies. J Med Ethics. Essentially all observers have stated that they believe that it would be ethical to insert genetic material into a human being for the sole purpose of medically correcting a severe genetic defect in that patient, that is somatic cell gene therapy. 2003 Sep-Dec;14(3-4):171-92. Another complex matter involves trying to determine appropriate reasons for choosing target diseases for research, for which the dichotomy between rare single-gene and common multifactorial diseases reveals an ongoing dilemma. Ethical debates in genetic engineering: U.S. scientists' attitudes on patenting, germ-line research, food labeling, and agri-biotech issues. USA.gov. 2003 Summer;28(3):365-402 To discern the ethical issues involved in current gene therapy research, to explore the problems inherent in possible future gene therapies, and to encourage debate within the scientific community about ethical questions relevant to both, we surveyed American Society of Human Genetics scientists who engage in human genetics research. 2013 Mar 4;15(3):e44. Please enable it to take advantage of the complete set of features! Politics Life Sci.

2003 Summer;28(3):365-402. doi: 10.1177/0162243903028003002. Published by Elsevier Inc. All rights reserved. J Med Ethics. By continuing you agree to the use of cookies. In this day and age, gene therapy is a new and innovative method to treat and prevent diseases by injecting a gene into a patient’s cell (Ama-assn.org, 2016). Immediate issues are the control and confidentiality of results of genetic testing, possible discrimination against those found to have genetic diseases, and the just allocation of beneficial genetic therapies. As gene therapy cures disease by generating modifications in the human body, many ethical and legal problems arise (Genetics Home Reference, 2016). We use cookies to help provide and enhance our service and tailor content and ads. J Cell Mol Med. 2019 Dec;31(49):e1903637. Since the early days of gene therapy at the end of the 1980s, both the scientific community and the public have perceived the ethical and social problems intrinsic to this discipline. : 1.1. Adv Mater. 2008 Oct;12(5B):1785-93. doi: 10.1111/j.1582-4934.2008.00460.x. HHS Ethical issues in genetic therapy involve the use of genetic science for human good and the avoidance of preventable harms.

Germ-line gene therapy, in The Ethics of Human Gene Therapy. The individual generally asks that his or her spouse be informed as well. -. The routinisation of genomics and genetics: implications for ethical practices.  |  Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Scientists generally agree that somatic gene therapy is one of the most promising ways of allowing to alleviate, to cure or to prevent a growing number of genetic as well as acquired diseases, including cancer and even perhaps AIDS. Germ-line gene modification and disease prevention: some medical and ethical perspectives. Human germ-line therapy: the case for its development and use. doi: 10.1002/adma.201903637. Non-professionals' evaluations of gene therapy ethics. NLM Such use as trait enhancement and “neo‐eugenics” raise troubling ethical concerns.  |  Less practical, but possibly more significant, dilemmas involve the use of genetic science in ways that go beyond prevention and cure of disease. Ethical issues in cellular and molecular medicine and tissue engineering. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. @article{Sade1998GeneTE, title={Gene therapy: ethical and social issues. Gene therapy: ethical and social issues. Ethical Issues of Using CRISPR Technologies for Research on Military Enhancement.

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