Add / edit notice, my watchlist In this work, we present the preclinical antitumor profile of the first-in-class ADC, MEN1309/OBT076, targeting tumors expressing the CD205 antigen. generation of hybridomas and speeds product development timelines by allowing researchers to move directly into pre-clinical assessment of mCR, complete response; mPD, progressive disease; mPR, partial response; mSD, stable disease. ABX-EGF is a fully human monoclonal antibody against the epidermal growth factor receptor (EGFr), a receptor identified in many solid tumor types. Unlimited viewing of the article/chapter PDF and any associated supplements and figures. Percent viability was calculated using wells incubated in the absence of ADC as the control and was plotted versus antibody concentration. The antitumor activity of MEN1309 on patient-derived xenograft (PDX) models was carried out at the Lab Animal Service at Campus Vall d'Hebron Animal Facility by the Growth Factors laboratory of Vall D'Hebron Institute of Oncology (Barcelona, Spain) and at Champions Oncology, Inc. (see details in Supplementary Materials and Methods). Arrows indicate treatment administration. The CD205 antigen, a transmembrane protein member of the macrophage mannose receptor family of C-type lectins, is an ideal target for an ADC-based therapy because it is highly overexpressed in different solid tumors compared with healthy tissues. Unexpectedly, the administration of IgG1-DM4 control ADC showed a very slight effect on tumor growth. ``Our comprehensive program of antibody technologies, which includes A. Pellacani is head of research and development at Menarini Ricerche and has ownership interest (including stock, patents, etc.) In fact, mass spectrometry of tumor cell membranes demonstrated that CD205 expression was elevated in pancreatic cancer compared with normal pancreas, and in TNBC compared with other breast cancer types (Fig. With an accout for my.chemeurope.com you can always see everything at a glance – and you can configure your own website and individual newsletter. MBH1309/OBT076-SPDB-DM4 and MBH1309/OBT076-MMC-DM1 antitumor activity on HPAFII xenograft tumors (showing homogenous staining for CD205; right) and Raji xenograft tumors (showing heterogeneous staining for CD205; left). Secondary antibody (goat anti-human IgG, FITC, Southern Biotech) was diluted to a concentration of 50 nmol/L in IF buffer and 200 μL added to each well for 60 minutes on ice. Briefly, human IgG1 antibody–producing Xenomice were immunized with the purified ECD of human nectin-4. Interestingly, in two xenograft models of TNBC expressing low CD205 antigen (weak staining with 1+ IHC score), 2.5 mg/Kg of MEN1309/OBT076 was able to completely inhibit the tumor growth. Consistent with the proteomics data, strong and specific CD205 staining was detected in TNBC (75% prevalence), bladder cancer (70% prevalence), and pancreatic tumors (68% prevalence), whereas it was much reduced in the corresponding normal tissues using a commercial CD205 antibody (Fig.

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